Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1

Anti-HIV-1 drug design has been notably challenging due to the virus’ ability to mutate and develop immunity against commercially available drugs. The aims of this project were to develop a series of fleximer base analogues that not only possess inherent flexibility that can remain active when faced...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Ku, Therese, Lopresti, Natalie, Shirley, Matthew, Mori, Mattia, Marchant, Jan, Heng, Xiao, Botta, Maurizio, Summers, Michael F., Seley-Radtke, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556414/
https://ncbi.nlm.nih.gov/pubmed/31126822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.05.019
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