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Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors
Bicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These analogues induce concentration-dependent degradation of Hsp90-dependent client proteins with the six-membered bicyclic analogues manifesting increased activity versus the five-membered counterparts.
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784232/ https://ncbi.nlm.nih.gov/pubmed/19896848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.091 |
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