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Design, Synthesis, and Biological Evaluation of Conformationally Constrained CIS-Amide Hsp90 Inhibitors
[Image: see text] Conformationally constrained CIS-amide chimeric inhibitors of Hsp90 have been synthesized and evaluated for their Hsp90 inhibitory activity. These new compounds exhibited Hsp90 ATPase inhibition and induced Hsp90-dependent client protein degradation in a dose-dependent manner. Biol...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697668/ https://ncbi.nlm.nih.gov/pubmed/19435295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900783m |
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