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Design, Synthesis, and Biological Evaluation of Conformationally Constrained CIS-Amide Hsp90 Inhibitors

[Image: see text] Conformationally constrained CIS-amide chimeric inhibitors of Hsp90 have been synthesized and evaluated for their Hsp90 inhibitory activity. These new compounds exhibited Hsp90 ATPase inhibition and induced Hsp90-dependent client protein degradation in a dose-dependent manner. Biol...

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書目詳細資料
Main Authors: Duerfeldt, Adam S., Brandt, Gary E. L., Blagg, Brian S. J.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697668/
https://ncbi.nlm.nih.gov/pubmed/19435295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900783m
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