Chargement en cours...
Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors
Bicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These analogues induce concentration-dependent degradation of Hsp90-dependent client proteins with the six-membered bicyclic analogues manifesting increased activity versus the five-membered counterparts.
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784232/ https://ncbi.nlm.nih.gov/pubmed/19896848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.091 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|