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Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters
We evaluate by simulation three model-based methods to test the influence of a single nucleotide polymorphism on a pharmacokinetic parameter of a drug: ANOVA on the empirical Bayes estimates of the individual parameters, likelihood ratio test between models with and without genetic covariate, and Wa...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Informa Healthcare
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784080/ https://ncbi.nlm.nih.gov/pubmed/18991109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543400802369012 |
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