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Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters
OBJECTIVES: Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Verlag
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1963422/ https://ncbi.nlm.nih.gov/pubmed/17404720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-007-0269-5 |
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