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Estimation of population pharmacokinetic parameters of saquinavir in HIV patients with the MONOLIX software
In nonlinear mixed-effects models, estimation methods based on a linearization of the likelihood are widely used although they have several methodological drawbacks. Kuhn and Lavielle (2005) developed an estimation method which combines the SAEM (Stochastic Approximation EM) algorithm, with a MCMC (...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Kluwer Academic/Plenum Publishers
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1974848/ https://ncbi.nlm.nih.gov/pubmed/17211713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-006-9043-z |
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