Development of a Complex Parent-Metabolite Joint Population Pharmacokinetic Model

This study aimed to develop a joint population pharmacokinetic model for an antipsychotic agent in development (S33138) and its active metabolite (S35424) produced by reversible metabolism. Because such a model leads to identifiability problems and numerical difficulties, the model building was perf...

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Bibliographic Details
Main Authors: Bertrand, Julie, Laffont, Céline M., Mentré, France, Chenel, Marylore, Comets, Emmanuelle
Format: Artigo
Language:Inglês
Published: Springer US 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160156/
https://ncbi.nlm.nih.gov/pubmed/21618059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9282-9
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