Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation

Within the developing pancreas Hepatic Nuclear Factor 6 (HNF6) directly activates the pro-endocrine transcription factor, Ngn3. HNF6 and Ngn3 are each essential for endocrine differentiation and HNF6 is also required for embryonic duct development. Most HNF6(−/−) animals die as neonates, making it d...

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Main Authors: Zhang, Hongjie, Ables, Elizabeth Tweedie, Pope, Christine F., Washington, M. Kay, Hipkens, Susan, Means, Anna L., Path, Gunter, Costa, Robert H., Seufert, Jochen, Leiter, Andrew B., Magnuson, Mark A., Gannon, Maureen
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783291/
https://ncbi.nlm.nih.gov/pubmed/19766716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mod.2009.09.006
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