Phosphatase and Tensin Homologue on Chromosome 10 (PTEN) Directs Prostaglandin E(2)-mediated Fibroblast Responses via Regulation of E Prostanoid 2 Receptor Expression

Prostaglandin E(2) (PGE(2)) is an arachidonic acid metabolite that counters transforming growth factor-β-induced fibroblast activation via E prostanoid 2 (EP2) receptor binding. Phosphatase and tensin homologue on chromosome 10 (PTEN) is a lipid phosphatase that, by antagonizing the phosphoinositol...

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Bibliographic Details
Main Authors: Sagana, Rommel L., Yan, Mei, Cornett, Ashley M., Tsui, Jessica L., Stephenson, David A., Huang, Steven K., Moore, Bethany B., Ballinger, Megan N., Melonakos, Janet, Kontos, Christopher D., Aronoff, David M., Peters-Golden, Marc, White, Eric S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781639/
https://ncbi.nlm.nih.gov/pubmed/19808686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.004796
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