Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on Gα Subunit

The simultaneous activation of many distinct G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play a major role in various pathological conditions. Pan-inhibition of GPCR signaling by small molecules thus represents a novel strategy to treat various diseases. To better understand su...

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Detalhes bibliográficos
Main Authors: Ayoub, Mohammed Akli, Damian, Marjorie, Gespach, Christian, Ferrandis, Eric, Lavergne, Olivier, De Wever, Olivier, Banères, Jean-Louis, Pin, Jean-Philippe, Prévost, Grégoire Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781458/
https://ncbi.nlm.nih.gov/pubmed/19648112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042333
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