Regulation of Immature Dendritic Cell Migration by RhoA Guanine Nucleotide Exchange Factor Arhgef5

There are a large number of Rho guanine nucleotide exchange factors, most of which have no known functions. Here, we carried out a short hairpin RNA-based functional screen of Rho-GEFs for their roles in leukocyte chemotaxis and identified Arhgef5 as an important factor in chemotaxis of a macrophage...

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Main Authors: Wang, Zhenglong, Kumamoto, Yosuke, Wang, Ping, Gan, Xiaoqing, Lehmann, David, Smrcka, Alan V., Cohn, Lauren, Iwasaki, Akiko, Li, Lin, Wu, Dianqing
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2009
Ábhair:
Mechanisms of Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781403/
https://ncbi.nlm.nih.gov/pubmed/19713215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047282
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