ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth

A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size of the heart, and fat deposition. Here, we have identified the repressor and fin...

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Detalhes bibliográficos
Main Authors: Markljung, Ellen, Jiang, Lin, Jaffe, Jacob D., Mikkelsen, Tarjei S., Wallerman, Ola, Larhammar, Martin, Zhang, Xiaolan, Wang, Li, Saenz-Vash, Veronica, Gnirke, Andreas, Lindroth, Anders M., Barrés, Romain, Yan, Jie, Strömberg, Sara, De, Sachinandan, Pontén, Fredrik, Lander, Eric S., Carr, Steven A., Zierath, Juleen R., Kullander, Klas, Wadelius, Claes, Lindblad-Toh, Kerstin, Andersson, Göran, Hjälm, Göran, Andersson, Leif
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780926/
https://ncbi.nlm.nih.gov/pubmed/20016685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000256
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