ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth

A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size of the heart, and fat deposition. Here, we have identified the repressor and fin...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Markljung, Ellen, Jiang, Lin, Jaffe, Jacob D., Mikkelsen, Tarjei S., Wallerman, Ola, Larhammar, Martin, Zhang, Xiaolan, Wang, Li, Saenz-Vash, Veronica, Gnirke, Andreas, Lindroth, Anders M., Barrés, Romain, Yan, Jie, Strömberg, Sara, De, Sachinandan, Pontén, Fredrik, Lander, Eric S., Carr, Steven A., Zierath, Juleen R., Kullander, Klas, Wadelius, Claes, Lindblad-Toh, Kerstin, Andersson, Göran, Hjälm, Göran, Andersson, Leif
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780926/
https://ncbi.nlm.nih.gov/pubmed/20016685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000256
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki