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Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells

The transcription factor ZBED6 (zinc finger, BED-type containing 6) is a repressor of IGF2 whose action impacts development, cell proliferation, and growth in placental mammals. In human colorectal cancers, IGF2 overexpression is mutually exclusive with somatic mutations in PI3K signaling components...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Akhtar Ali, Muhammad, Younis, Shady, Wallerman, Ola, Gupta, Rajesh, Andersson, Leif, Sjöblom, Tobias
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485122/
https://ncbi.nlm.nih.gov/pubmed/26056301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509193112
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