The ZBED6–IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals

A single nucleotide substitution in the third intron of insulin-like growth factor 2 (IGF2) is associated with increased muscle mass and reduced subcutaneous fat in domestic pigs. This mutation disrupts the binding of the ZBED6 transcription factor and leads to a threefold up-regulation of IGF2 expr...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Younis, Shady, Schönke, Milena, Massart, Julie, Hjortebjerg, Rikke, Sundström, Elisabeth, Gustafson, Ulla, Björnholm, Marie, Krook, Anna, Frystyk, Jan, Zierath, Juleen R., Andersson, Leif
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834713/
https://ncbi.nlm.nih.gov/pubmed/29440408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719278115
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