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The ZBED6–IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals
A single nucleotide substitution in the third intron of insulin-like growth factor 2 (IGF2) is associated with increased muscle mass and reduced subcutaneous fat in domestic pigs. This mutation disrupts the binding of the ZBED6 transcription factor and leads to a threefold up-regulation of IGF2 expr...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5834713/ https://ncbi.nlm.nih.gov/pubmed/29440408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719278115 |
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