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Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites

Conserved noncoding elements (CNEs) constitute the majority of sequences under purifying selection in the human genome, yet their function remains largely unknown. Experimental evidence suggests that many of these elements play regulatory roles, but little is known about regulatory motifs contained...

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Detalhes bibliográficos
Main Authors: Xie, Xiaohui, Mikkelsen, Tarjei S., Gnirke, Andreas, Lindblad-Toh, Kerstin, Kellis, Manolis, Lander, Eric S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852749/
https://ncbi.nlm.nih.gov/pubmed/17442748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701811104
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