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Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites

Conserved noncoding elements (CNEs) constitute the majority of sequences under purifying selection in the human genome, yet their function remains largely unknown. Experimental evidence suggests that many of these elements play regulatory roles, but little is known about regulatory motifs contained...

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Autori principali: Xie, Xiaohui, Mikkelsen, Tarjei S., Gnirke, Andreas, Lindblad-Toh, Kerstin, Kellis, Manolis, Lander, Eric S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852749/
https://ncbi.nlm.nih.gov/pubmed/17442748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701811104
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