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Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin

Noncovalent binding interactions between proteins are the central physicochemical phenomenon underlying biological signaling and functional control on the molecular level. Here, we perform an extensive structural analysis of a large set of bound and unbound ubiquitin conformers and study the level o...

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Autori principali: Wlodarski, Tomasz, Zagrovic, Bojan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780739/
https://ncbi.nlm.nih.gov/pubmed/19887638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906966106
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