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Two-state selection of conformation-specific antibodies
We present a general strategy for identification of conformation-specific antibodies using phage display. Different covalent probes were used to trap caspase-1 into 2 alternative conformations, termed the on-form and the off-form. These conformation-trapped forms of the protease were used as antigen...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651286/ https://ncbi.nlm.nih.gov/pubmed/19208804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812952106 |
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