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Conformational selection or induced fit: A flux description of reaction mechanism

The mechanism of ligand binding coupled to conformational changes in macromolecules has recently attracted considerable interest. The 2 limiting cases are the “induced fit” mechanism (binding first) or “conformational selection” (conformational change first). Described here are the criteria by which...

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Detalhes bibliográficos
Principais autores: Hammes, Gordon G., Chang, Yu-Chu, Oas, Terrence G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728963/
https://ncbi.nlm.nih.gov/pubmed/19666553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907195106
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