AAV3-mediated Transfer and Expression of the Pyruvate Dehydrogenase E1 alpha Subunit Gene Causes Metabolic Remodeling and Apoptosis of Human Liver Cancer Cells

Most cancers rely disproportionately on glycolysis for energy even in the presence of adequate oxygen supply, a condition known as “aerobic glycolysis”, or the Warburg effect. Pharmacological reversal of the Warburg effect has been shown to cause selective apoptosis of tumor cells, presumably by sti...

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Main Authors: Glushakova, Lyudmyla G., Lisankie, Matthew J., Eruslanov, Evgeniy B., Ojano-Dirain, Carolyn, Zolotukhin, Irene, Liu, Chen, Srivastava, Arun, Stacpoole, Peter W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779054/
https://ncbi.nlm.nih.gov/pubmed/19586787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2009.05.010
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