An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α

We evaluated the feasibility of self-complementary adeno-associated virus (scAAV) vector-mediated knockdown of the pyruvate dehydrogenase complex using small interfering RNAs directed against the E1α subunit gene (PDHA1). AAV serotype 8 was used to stereotaxically deliver scAAV8-si3-PDHA1-Enhanced G...

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Autori principali: Ojano-Dirain, Carolyn, Glushakova, Lyudmyla G., Zhong, Li, Zolotukhin, Sergei, Muzyczka, Nicholas, Srivastava, Arun, Stacpoole, Peter W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950252/
https://ncbi.nlm.nih.gov/pubmed/20685142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2010.07.008
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