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Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts
The pyruvate dehydrogenase complex (PDC) oxidizes pyruvate to acetyl CoA and is critically important in maintaining normal cellular energy homeostasis. Loss-of-function mutations in PDC give rise to congenital lactic acidosis and to progressive cellular energy failure. However, the subsequent bioche...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205311/ https://ncbi.nlm.nih.gov/pubmed/21846590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2011.07.023 |
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