Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts

The pyruvate dehydrogenase complex (PDC) oxidizes pyruvate to acetyl CoA and is critically important in maintaining normal cellular energy homeostasis. Loss-of-function mutations in PDC give rise to congenital lactic acidosis and to progressive cellular energy failure. However, the subsequent bioche...

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Bibliographic Details
Main Authors: Glushakova, Lyudmyla G., Judge, Sharon, Cruz, Alex, Pourang, Deena, Mathews, Clayton E., Stacpoole, Peter W.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205311/
https://ncbi.nlm.nih.gov/pubmed/21846590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2011.07.023
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