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Pyruvate Dehydrogenase Complex Activity in Normal and Deficient Fibroblasts

Pyruvate dehydrogenase complex (PDC) activity in human skin fibroblasts appears to be regulated by a phosphorylation-dephosphorylation mechanism, as is the case with other animal cells. The enzyme can be activated by pretreating the cells with dichloroacetate (DCA), an inhibitor of pyruvate dehydrog...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Sheu, Kwan-Fu Rex, Hu, Chii-Whei C., Utter, Merton F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1981
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370714/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6262377/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110176
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