Genetic influence on the structural variations of the abnormal prion protein

Prion diseases are characterized by the presence of the abnormal prion protein PrP(Sc), which is believed to be generated by the conversion of the α-helical structure that predominates in the normal PrP isoform into a β-sheet structure resistant to proteinase K (PK). In human prion diseases, two maj...

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Bibliografski detalji
Glavni autori: Parchi, Piero, Zou, Wenquan, Wang, Wen, Brown, Paul, Capellari, Sabina, Ghetti, Bernardino, Kopp, Nicolas, Schulz-Schaeffer, Walter J., Kretzschmar, Hans A., Head, Mark W., Ironside, James W., Gambetti, Pierluigi, Chen, Shu G.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC27779/
https://ncbi.nlm.nih.gov/pubmed/10963679
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