Genetic influence on the structural variations of the abnormal prion protein

Prion diseases are characterized by the presence of the abnormal prion protein PrP(Sc), which is believed to be generated by the conversion of the α-helical structure that predominates in the normal PrP isoform into a β-sheet structure resistant to proteinase K (PK). In human prion diseases, two maj...

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Detalhes bibliográficos
Main Authors: Parchi, Piero, Zou, Wenquan, Wang, Wen, Brown, Paul, Capellari, Sabina, Ghetti, Bernardino, Kopp, Nicolas, Schulz-Schaeffer, Walter J., Kretzschmar, Hans A., Head, Mark W., Ironside, James W., Gambetti, Pierluigi, Chen, Shu G.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27779/
https://ncbi.nlm.nih.gov/pubmed/10963679
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