Genetic influence on the structural variations of the abnormal prion protein

Prion diseases are characterized by the presence of the abnormal prion protein PrP(Sc), which is believed to be generated by the conversion of the α-helical structure that predominates in the normal PrP isoform into a β-sheet structure resistant to proteinase K (PK). In human prion diseases, two maj...

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Главные авторы: Parchi, Piero, Zou, Wenquan, Wang, Wen, Brown, Paul, Capellari, Sabina, Ghetti, Bernardino, Kopp, Nicolas, Schulz-Schaeffer, Walter J., Kretzschmar, Hans A., Head, Mark W., Ironside, James W., Gambetti, Pierluigi, Chen, Shu G.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2000
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC27779/
https://ncbi.nlm.nih.gov/pubmed/10963679
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