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Rabex-5 Is a Rab22 Effector and Mediates a Rab22-Rab5 Signaling Cascade in Endocytosis

Rabex-5 targets to early endosomes and functions as a guanine nucleotide exchange factor for Rab5. Membrane targeting is critical for Rabex-5 to activate Rab5 on early endosomes in the cell. Here, we report the identification of Rab22 as a binding site on early endosomes for direct recruitment of Ra...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Huaiping, Liang, Zhimin, Li, Guangpu
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777102/
https://ncbi.nlm.nih.gov/pubmed/19759177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-06-0453
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