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Purification, crystallization and preliminary X-ray diffraction experiments on the breakage-reunion domain of the DNA gyrase from Mycobacterium tuberculosis

Mycobacterium tuberculosis DNA gyrase, a nanomachine that is involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and hence is the sole target for fluoroquinolone action. The breakage-reunion domain of the A subunit plays an essential role in DNA bin...

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Main Authors: Piton, Jérémie, Matrat, Stéphanie, Petrella, Stéphanie, Jarlier, Vincent, Aubry, Alexandra, Mayer, Claudine
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777054/
https://ncbi.nlm.nih.gov/pubmed/19923746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109042067
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