Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase ATPase domain

Mycobacterium tuberculosis DNA gyrase, a nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and hence is the sole target of fluoroquinolones in the treatment of tuberculosis. The ATPase domain provides the energy required for catalysis...

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Bibliographic Details
Main Authors: Roué, Mélanie, Agrawal, Alka, Volker, Craig, Mossakowska, Danuta, Mayer, Claudine, Bax, Benjamin D.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2013
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668594/
https://ncbi.nlm.nih.gov/pubmed/23722853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309113012906
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