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Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase
Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against multidrug-resistant tuberculosis. To understand...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923608/ https://ncbi.nlm.nih.gov/pubmed/20805881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012245 |
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