Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase

Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against multidrug-resistant tuberculosis. To understand...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Piton, Jérémie, Petrella, Stéphanie, Delarue, Marc, André-Leroux, Gwénaëlle, Jarlier, Vincent, Aubry, Alexandra, Mayer, Claudine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2010
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923608/
https://ncbi.nlm.nih.gov/pubmed/20805881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012245
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