Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase

Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against multidrug-resistant tuberculosis. To understand...

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Bibliografske podrobnosti
Main Authors: Piton, Jérémie, Petrella, Stéphanie, Delarue, Marc, André-Leroux, Gwénaëlle, Jarlier, Vincent, Aubry, Alexandra, Mayer, Claudine
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923608/
https://ncbi.nlm.nih.gov/pubmed/20805881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012245
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