Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase

Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against multidrug-resistant tuberculosis. To understand...

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Main Authors: Piton, Jérémie, Petrella, Stéphanie, Delarue, Marc, André-Leroux, Gwénaëlle, Jarlier, Vincent, Aubry, Alexandra, Mayer, Claudine
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2010
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923608/
https://ncbi.nlm.nih.gov/pubmed/20805881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012245
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