Extending the Definition of the GyrB Quinolone Resistance-Determining Region in Mycobacterium tuberculosis DNA Gyrase for Assessing Fluoroquinolone Resistance in M. tuberculosis

Fluoroquinolone (FQ) resistance is emerging in Mycobacterium tuberculosis. The main mechanism of FQ resistance is amino acid substitution within the quinolone resistance-determining region (QRDR) of the GyrA subunit of DNA gyrase, the sole FQ target in M. tuberculosis. However, substitutions in GyrB...

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Detalhes bibliográficos
Main Authors: Pantel, Alix, Petrella, Stéphanie, Veziris, Nicolas, Brossier, Florence, Bastian, Sylvaine, Jarlier, Vincent, Mayer, Claudine, Aubry, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318379/
https://ncbi.nlm.nih.gov/pubmed/22290942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06272-11
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