DNA Gyrase Inhibition Assays Are Necessary To Demonstrate Fluoroquinolone Resistance Secondary to gyrB Mutations in Mycobacterium tuberculosis

The main mechanism of fluoroquinolone (FQ) resistance in Mycobacterium tuberculosis is mutation in DNA gyrase (GyrA(2)GyrB(2)), especially in gyrA. However, the discovery of unknown mutations in gyrB whose implication in FQ resistance is unclear has become more frequent. We investigated the impact o...

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Detalhes bibliográficos
Main Authors: Pantel, Alix, Petrella, Stéphanie, Matrat, Stéphanie, Brossier, Florence, Bastian, Sylvaine, Reitter, Delphine, Jarlier, Vincent, Mayer, Claudine, Aubry, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186962/
https://ncbi.nlm.nih.gov/pubmed/21768507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00707-11
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