DNA Gyrase Inhibition Assays Are Necessary To Demonstrate Fluoroquinolone Resistance Secondary to gyrB Mutations in Mycobacterium tuberculosis

The main mechanism of fluoroquinolone (FQ) resistance in Mycobacterium tuberculosis is mutation in DNA gyrase (GyrA(2)GyrB(2)), especially in gyrA. However, the discovery of unknown mutations in gyrB whose implication in FQ resistance is unclear has become more frequent. We investigated the impact o...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Pantel, Alix, Petrella, Stéphanie, Matrat, Stéphanie, Brossier, Florence, Bastian, Sylvaine, Reitter, Delphine, Jarlier, Vincent, Mayer, Claudine, Aubry, Alexandra
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2011
الموضوعات:
Mechanisms of Resistance
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186962/
https://ncbi.nlm.nih.gov/pubmed/21768507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00707-11
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