Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN

Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface receptors, the other with secreted antagonists that act as ligand traps. We identified two mutations (N445K,T) in patients with multiple syno...

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Autori principali: Seemann, Petra, Brehm, Anja, König, Jana, Reissner, Carsten, Stricker, Sigmar, Kuss, Pia, Haupt, Julia, Renninger, Stephanie, Nickel, Joachim, Sebald, Walter, Groppe, Jay C., Plöger, Frank, Pohl, Jens, Schmidt-von Kegler, Mareen, Walther, Maria, Gassner, Ingmar, Rusu, Cristina, Janecke, Andreas R., Dathe, Katarina, Mundlos, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776984/
https://ncbi.nlm.nih.gov/pubmed/19956691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000747
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