Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

West Nile Virus (WNV) is a potentially deadly mosquito-borne flavivirus which has spread rapidly throughout the world. Currently there is no effective vaccine against flaviviral infections. We previously reported the identification of pyrazole ester derivatives as allosteric inhibitors of WNV NS2B-N...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Sidique, Shyama, Shiryaev, Sergey A., Ratnikov, Boris I., Herath, Ananda, Su, Ying, Strongin, Alex Y., Cosford, Nicholas D. P.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2009
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776708/
https://ncbi.nlm.nih.gov/pubmed/19703770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.07.150
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