p21(CIP1) attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

p21(CIP1/WAF1) is a downstream effector of tumor suppressors and functions as a cyclin-dependent kinase inhibitor to block cellular proliferation. Breast tumors may derive from self-renewing tumor-initiating cells (BT-ICs), which contribute to tumor progression, recurrence, and therapy resistance. T...

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Autori principali: Liu, Manran, Casimiro, Mathew C., Wang, Chenguang, Shirley, L. Andrew, Jiao, Xuanmao, Katiyar, Sanjay, Ju, Xiaoming, Li, Zhiping, Yu, Zuoren, Zhou, Jie, Johnson, Michael, Fortina, Paolo, Hyslop, Terry, Windle, Jolene J., Pestell, Richard G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776463/
https://ncbi.nlm.nih.gov/pubmed/19858489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910009106
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