p21(CIP1) attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

p21(CIP1/WAF1) is a downstream effector of tumor suppressors and functions as a cyclin-dependent kinase inhibitor to block cellular proliferation. Breast tumors may derive from self-renewing tumor-initiating cells (BT-ICs), which contribute to tumor progression, recurrence, and therapy resistance. T...

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Bibliographic Details
Main Authors: Liu, Manran, Casimiro, Mathew C., Wang, Chenguang, Shirley, L. Andrew, Jiao, Xuanmao, Katiyar, Sanjay, Ju, Xiaoming, Li, Zhiping, Yu, Zuoren, Zhou, Jie, Johnson, Michael, Fortina, Paolo, Hyslop, Terry, Windle, Jolene J., Pestell, Richard G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776463/
https://ncbi.nlm.nih.gov/pubmed/19858489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910009106
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