A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation

Decreased expression of specific microRNAs (miRNAs) occurs in human tumors, which suggests a function for miRNAs in tumor suppression. Herein, levels of the miR-17-5p/miR-20a miRNA cluster were inversely correlated to cyclin D1 abundance in human breast tumors and cell lines. MiR-17/20 suppressed br...

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Detalhes bibliográficos
Main Authors: Yu, Zuoren, Wang, Chenguang, Wang, Min, Li, Zhiping, Casimiro, Mathew C., Liu, Manran, Wu, Kongming, Whittle, James, Ju, Xiaoming, Hyslop, Terry, McCue, Peter, Pestell, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2500136/
https://ncbi.nlm.nih.gov/pubmed/18695042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801079
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