Distinct Argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline

Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse biological processes. Here, we combine deep-sequencing and genetic approaches to explore the biogenesis and function of endo-siRNAs in C. elegans. We describe conditional all...

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Main Authors: Gu, Weifeng, Shirayama, Masaki, Conte, Darryl, Vasale, Jessica, Batista, Pedro J., Claycomb, Julie M., Moresco, James J., Youngman, Elaine, Keys, Jennifer, Stoltz, Matthew J., Chen, Chun-Chieh G., Chaves, Daniel A., Duan, Shenghua E., Kasschau, Kristen D., Falgren, Noah, Yates, John R., Mitani, Shohei, Carrington, James C., Mello, Craig C.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776052/
https://ncbi.nlm.nih.gov/pubmed/19800275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.020
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