The Argonaute CSR-1 and its 22G-RNA co-factors target germline genes and are required for holocentric chromosome segregation

RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related helicase DRH-3, and the Tudor-domain protein EKL-1 localize to chromosomes and are requ...

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Autori principali: Claycomb, Julie M., Batista, Pedro J., Pang, Ka Ming, Gu, Weifeng, Vasale, Jessica J., van Wolfswinkel, Josien C., Chaves, Daniel A., Shirayama, Masaki, Mitani, Shohei, Ketting, René F., Conte, Darryl, Mello, Craig C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766185/
https://ncbi.nlm.nih.gov/pubmed/19804758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.09.014
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