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Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation
BACKGROUND: Oxidative stress, generated by excessive reactive oxygen species (ROS) promotes cardiovascular disease. Cyclophilin A (CyPA) is a 20 kD chaperone protein secreted from vascular smooth muscle cells (VSMC) in response to ROS, which stimulates VSMC proliferation and inflammatory cell migrat...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775430/ https://ncbi.nlm.nih.gov/pubmed/18541741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.756106 |
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