Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

BACKGROUND: Oxidative stress, generated by excessive reactive oxygen species (ROS) promotes cardiovascular disease. Cyclophilin A (CyPA) is a 20 kD chaperone protein secreted from vascular smooth muscle cells (VSMC) in response to ROS, which stimulates VSMC proliferation and inflammatory cell migrat...

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Detalhes bibliográficos
Main Authors: Satoh, Kimio, Matoba, Tetsuya, Suzuki, Jun, O'Dell, Michael R., Nigro, Patrizia, Cui, Zhaoqiang, Mohan, Amy, Pan, Shi, Li, Lingli, Jin, Zheng-Gen, Yan, Chen, Abe, Jun-ichi, Berk, Bradford C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775430/
https://ncbi.nlm.nih.gov/pubmed/18541741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.756106
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