Cyclophilin A enhances vascular oxidative stress and development of angiotensin II-induced aortic aneurysms

Inflammation and oxidative stress are pathogenic mediators of many diseases, but therapeutic targets remain elusive. In the vasculature, abdominal aortic aneurysm (AAA) formation critically involves inflammaton and matrix degradation. Cyclophilin A (CyPA, encoded by Ppia) is highly expressed in vasc...

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Main Authors: Satoh, Kimio, Nigro, Patrizia, Matoba, Tetsuya, O'Dell, Michael R., Cui, Zhaoqiang, Shi, Xi, Mohan, Amy, Yan, Chen, Abe, Jun-ichi, Illig, Karl A., Berk, Bradford C.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704983/
https://ncbi.nlm.nih.gov/pubmed/19430489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1958
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