Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis

Canonical chromosomal translocations juxtaposing antigen receptor genes and oncogenes are a hallmark of many lymphoid malignancies. These translocations frequently form through the joining of DNA ends from double-strand breaks (DSBs) generated by the recombinase activating gene (RAG)-1 and -2 protei...

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Bibliographic Details
Main Authors: Mahowald, Grace K., Baron, Jason M., Mahowald, Michael A., Kulkarni, Shashikant, Bredemeyer, Andrea L., Bassing, Craig H., Sleckman, Barry P.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775277/
https://ncbi.nlm.nih.gov/pubmed/19820166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902545106
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