Induction and Reversal of Cardiac Phenotype of Human Hypertrophic Cardiomyopathy Mutation Cardiac Troponin T-Q92 in Switch on-Switch Off Bigenic Mice

OBJECTIVES: To establish reversibility of cardiac phenotypes in hypertrophic cardiomyopathy (HCM) by generating bigenic mice in which expression of the mutant transgene could be turned on and off as needed. BACKGROUND: Advances in molecular therapeutics could ultimately lead to therapies aimed at co...

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Main Authors: Lutucuta, Silvia, Tsybouleva, Natalia, Ishiyama, Masukuni, DeFreitas, Gilberto, Wei, Lei, Carabello, Blasé, Marian, AJ
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774751/
https://ncbi.nlm.nih.gov/pubmed/15582321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2004.09.005
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