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Induction and Reversal of Cardiac Phenotype of Human Hypertrophic Cardiomyopathy Mutation Cardiac Troponin T-Q92 in Switch on-Switch Off Bigenic Mice
OBJECTIVES: To establish reversibility of cardiac phenotypes in hypertrophic cardiomyopathy (HCM) by generating bigenic mice in which expression of the mutant transgene could be turned on and off as needed. BACKGROUND: Advances in molecular therapeutics could ultimately lead to therapies aimed at co...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774751/ https://ncbi.nlm.nih.gov/pubmed/15582321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2004.09.005 |
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