Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy

BACKGROUND: Hypertrophic cardiomyopathy is a genetic disease characterized by cardiac hypertrophy, myocyte disarray, interstitial fibrosis, and left ventricular (LV) dysfunction. We have proposed that hypertrophy and fibrosis, the major determinants of mortality and morbidity, are potentially revers...

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Main Authors: Patel, Rajnikant, Nagueh, Sherif F., Tsybouleva, Natalie, Abdellatif, Maha, Lutucuta, Silvia, Kopelen, Helen A., Quinones, Miguel A., Zoghbi, William A., Entman, Mark L., Roberts, Robert, Marian, A.J.
Format: Artigo
Language:Inglês
Published: 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768618/
https://ncbi.nlm.nih.gov/pubmed/11457751
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