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ThPOK Derepression Is Required for Robust CD8 T cell Responses to Viral Infection
In the thymus, the transcription factor ThPOK is essential for the development of the CD4 helper T cell lineage, whereas active repression of ThPOK is critical for the development of the CD8 cytotoxic T cell lineage. ThPOK gene silencing is thought to be irreversible in peripheral CD8 T cells. We no...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774709/ https://ncbi.nlm.nih.gov/pubmed/19734230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901428 |
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