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The ThPOK transcription factor differentially affects the development and function of self-specific CD8(+) T cells and regulatory CD4(+) T cells

The zinc finger transcription factor ThPOK plays a crucial role in CD4 T-cell development and CD4/CD8 lineage decision. In ThPOK-deficient mice, developing T cells expressing MHC class II-restricted T-cell receptors are redirected into the CD8 T-cell lineage. In this study, we investigated whether t...

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Hlavní autoři: Twu, Yuh-Ching, Teh, Hung-Sia
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930380/
https://ncbi.nlm.nih.gov/pubmed/24708418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12205
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