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A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4(+) T cells
The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK...
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| Veröffentlicht in: | Nat Immunol |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4251968/ https://ncbi.nlm.nih.gov/pubmed/25129370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2960 |
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